TRANSLATIONAL CARDIAC MR RESEARCH CENTER

Our Mission:

To advance pre-clinical and clinical cardiovascular research at the University of Washington by implementation state-of-the-art MRI technology. Our research is focused on improving non-invasive imaging technology for assessment of heart physiology, pathophysiology on patients and animal models of human cardiovascular diseases, including myocardial infarction, congenital heart disease, and peripheral vascular disease, characterizing blood supply and assessment of treatment outcome.

We are open to new collaborations in heart studies on animals and humans!

Non-human primate's heart

Cardiac Magnetic Resonance Imaging (CMRI)

CMRI is a medical imaging technology for the non-invasive assessment of the structure and function of the heart. CMRI uses magnets (0.5–14 Tesla magnetic field strength) to polarize the hydrogen nuclei in water molecules in human and animal tissues. Combinations of time-varying gradient magnetic fields and pulse sequences of radio frequency waves provide the spatial distribution of signals emitted from protons, which are displayed as high-resolution, multidimensional images. MRI does not use ionizing radiation and can be performed serially over time. It is the most versatile imaging modality with superior sensitivity in detecting morphology, pathology and function.

Benefits of cardiac MRI:
  • Subject selection. Imaging is essential for determining whether subjects meet inclusion or exclusion criteria for entry into the pre-clinical and clinical trials.
  • Subject evaluation. Diagnostic imaging can define the extent of pathology and organ dysfunction for treatment planning.
  • Evaluation of anatomy and physiology (heart contractile function).
  • Non-invasive evaluation of tissue viability and infarct size.
  • Assessment of vascularity and blood flow.
  • Imaging of inflammation
  • Assessment the degree of fibrosis.
  • Transplanted cell tracking.

Short axis CINE multislice. Non-human primate.

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