TRANSLATIONAL CARDIAC MR RESEARCH CENTER

Anna V. Naumova, Ph.D.

Dr. Naumova is a Research Associate Professor at the Department of Radiology, UW Medicine. She has a long standing interest in biomedical imaging of cardiac regeneration. Her research is focused on development of non-invasive imaging techniques for visualization of transplanted cells. Specifically, she is using ferritin overexpression for cells tracking with MRI and developing a multifunctional gene reporter system for multimodality imaging of transplanted cell fate and function. Dr. Naumova is collaborating with other UW faculties in development of non-invasive imaging techniques to bridge the gap between cardiac therapies and subsequent health outcome. Dr. Naumova has shown improvement of heart contractility after human cardiomyocyte transplantation to the hearts of rodents and non-human primates in collaboration with Dr. Murry. Also, Dr. Naumova is developing MRI techniques based on the endogenous contrast mechanisms and its applications for improvement of tissue contrast in high magnetic fields (collaboration with Dr. Yarnykh). The ultimate goal of Dr. Naumova’s research is to bring new quantitative imaging technologies to address the unmet needs of the regenerative medicine, myocardial tissue characterization and heart failure treatment outcome with transplanted cells.

Anna Naumova graduated with honors from the Tomsk State University (Russia) with an MS in biology and applied informatics; then she obtained PhD from the Institute of Cardiology (Tomsk, Russia). During her postdoctoral fellowship at the Johns Hopkins University (Baltimore, MD, USA) Dr. Naumova studied cardiac energy metabolism and function using 1H magnetic resonance imaging (MRI) and spatially localized 31P MR spectroscopy in mouse models of human diseases (mentors: Robert G. Weiss, MD, PhD, and V.P. Chacko, PhD). During postdoctoral fellowship at the Vascular Imaging Laboratory (University of Washington, Seattle, WA, USA) Dr. Naumova investigated pathophysiological mechanisms of atherosclerosis and efficacy of human stem cell derived cardiomyocyte transplantation into the infarcted heart on animal models (mentors: Chun Yuan, PhD and Charles E. Murry, MD, PhD).

Selected publications:

1. Naumova AV, Weiss RG, Chacko VP. Regulation of Murine Myocardial Energy Metabolism During Adrenergic Stress Studied by In Vivo Phosphorus-31 NMR Spectroscopy. Am J Physiol Heart Circ Physiol 2003; 285(5): H1976-1979. PMID: 12881208.

2. Naumova AV, Chacko VP, Ouwerkerk R, Stull L, Marban E, Weiss RG. Xanthine Oxidase Inhibitors Improve Energetics and Function Following Infarction in the Failing Mouse Heart. Am J Physiol Heart Circ Physiol 2006; 290: H837-H843. PMID: 16183726.

3. Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Xu C, Hassanipour M, Police S, O’Sullivan C, Collins L, Minami E, Gill E.A, Ueno S, Yuan C, Gold J, Murry CE. Delivery of Human Embryonic Stem Cell Cardiomyocytes in Pro-Survival Factors Enhances the Function of Infarcted Hearts. Nature Biotechnol, 2007, 25: 1015–1024.

4. Naumova AV, Reinecke H, Yarnykh V, Deem J, Yuan C, Murry CE. Ferritin Overexpression for Noninvasive MRI-Based Tracking of Stem Cells Transplanted into the Heart. J Mol Imaging, 2010, 9 (4): 201-210. PMID: 20643023. PMC4082401.

5. Naumova AV, Yarnykh VL, Balu N, Reinecke H, Murry CE, Yuan C. Quantification of MRI Signal of Transgenic Grafts Overexpressing Ferritin in Murine Myocardial Infarcts. NMR Biomed. 2012; 25(10): 1187-1195. PMID: 22362654. PMCID: PMC3389131.

6. Kerwin WS, Naumova AV, Storb R, Tapscott S, Wang Z. Mapping contrast agent uptake and retention in CMRI studies of myocardial perfusion: Case control study of dogs with Duchenne Muscular Dystrophy. Int J Cardiovasc Imaging, 2013 Apr;29(4):819-26. PMCID: PMC3594362.

7. Naumova AV, Balu N, Yarnykh VL, Reinecke H, Murry CE, Yuan C. MRI Tracking of Graft Survival in the Infarcted Heart: Iron Oxide Particles vs. Ferritin Overexpression Approach. J Cardiovasc Pharmacol Ther. 2014 Mar 30;19(4):358-367. PMCID: PMC4185000.

8. Naumova AV, Modo M, Moore A, Murry CE, Frank JA. Clinical imaging to track cell fate and function in regenerative medicine. Invited review. Nature Biotechnol, 2014 Aug 5;32(8):804-818. PMCID: PMC4164232. Response to cardiac regeneration validated. Nature Biotechnol, 2015 Jun;33(6):587. PMID: 26057970.

9. Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL. High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields. Neuroimage, 2017 Feb 15;147:985-993. PMID: 27646128.

10. Naumova AV, Vande Velde G. Genetically encoded iron-associated proteins as MRI reporters for molecular and cellular imaging. WIREs Nanomedicine & Nanobiotechnology. May 2017