TRANSLATIONAL CARDIAC MR RESEARCH CENTER

Dr. Chun Yuan, PhD's work has centered around the development of methods to better predict stroke and cardiovascular events using novel applications of magnetic resonance imaging (MRI). In particular he has pioneered the techniques for, and has been instrumental in establishing, the field of Vulnerable Plaque imaging for atherosclerosis. He is also recognized for his distinct service to many professional societies: he has been a Member of the HRP Advisory Board (high-risk plaque), the AHA Council of CV Radiology & Intervention, Program Committee, the International Society for Magnetic Resonance in Medicine Award Committee (ISRMRM), and the Radiology Advisory Network at Philips Medical. Importantly, he is both a Fellow of ISMRM and the AHA Council of CV Radiology & Intervention. He also serves as a member of the NIH Medical Imaging Study Section (MEDI).

Dr. Yuan began at the University of Washington as an Assistant Professor in 1991 and promoted to Associate Professor of Radiology, and Adjunct Associate Professor of Bioengineering and Electrical Engineering in 1997. In 1997, he and Dr. Hatuskami established the Vascular Imaging Laboratory, which they continue to co-direct, and in 2006 Dr. Yuan established the Bio-Molecular Imaging Center, which has been key in providing imaging services to bioengineering and medical researchers. He is currently a tenured Professor in the Departments of Radiology and BioEnginering.

Publications:

  1. Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation. 2002 Sep 10;106(11):1368-73. PubMed PMID: 12221054.
  2. Kerwin WS, O'Brien KD, Ferguson MS, Polissar N, Hatsukami TS, Yuan C. Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study. Radiology. 2006 Nov;241(2):459-68. PubMed PMID: 16966482; PubMed Central PMCID:PMC1820770.
  3. Underhill HR, Hatsukami TS, Fayad ZA, Fuster V, Yuan C. MRI of carotid atherosclerosis: clinical implications and future directions. Nat Rev Cardiol. 2010 Mar;7(3):165-73. PubMed PMID: 20101259.
  4. Wang J, Börnert P, Zhao H, Hippe DS, Zhao X, Balu N, Ferguson MS, Hatsukami TS, Xu J, Yuan C, Kerwin WS. Simultaneous noncontrast angiography and intraplaque hemorrhage (SNAP) imaging for carotid atherosclerotic disease evaluation. Magn Reson Med. 2013 Feb;69(2):337-45. PubMed PMID: 22442116; PubMed Central PMCID: PMC3418400.
  5. Schmalbrock P, Yuan C, Chakeres DW, Kohli J, Pelc NJ. Volume MR angiography: methods to achieve very short echo times. Radiology. 1990 Jun;175(3):861-5. PubMed PMID: 2343137
  6. Parker DL, Yuan C, Blatter DD. MR angiography by multiple thin slab 3D acquisition. Magn Reson Med. 1991 Feb;17(2):434-51. PubMed PMID: 2062215.
  7. Yarnykh VL, Yuan C. T1-insensitive flow suppression using quadruple inversion-recovery. Magn Reson Med. 2002 Nov;48(5):899-905. PubMed PMID: 12418006.
  8. Wang J, Yarnykh VL, Hatsukami T, Chu B, Balu N, Yuan C. Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence. Magn Reson Med. 2007 Nov;58(5):973-81. PubMed PMID: 17969103.
  9. Hatsukami TS, Ross R, Polissar NL, Yuan C. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation. 2000 Aug 29;102(9):959-64. PubMed PMID: 10961958.
  10. Yuan C, Mitsumori LM, Ferguson MS, Polissar NL, Echelard D, Ortiz G, Small R, Davies JW, Kerwin WS, Hatsukami TS. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation. 2001 Oct 23;104(17):2051-6. PubMed PMID: 11673345.
  11. Yuan C, Mitsumori LM, Beach KW, Maravilla KR. Carotid atherosclerotic plaque: noninvasive MR characterization and identification of vulnerable lesions. Radiology. 2001 Nov;221(2):285-99. PubMed PMID: 11687667.
  12. Saam T, Ferguson MS, Yarnykh VL, Takaya N, Xu D, Polissar NL, Hatsukami TS, Yuan C. Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):234-9. PubMed PMID: 15528475.
  13. Yuan C, Kerwin WS, Ferguson MS, Polissar N, Zhang S, Cai J, Hatsukami TS. Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization. J Magn Reson Imaging. 2002 Jan;15(1):62-7. PubMed PMID: 11793458
  14. Kerwin WS, O'Brien KD, Ferguson MS, Polissar N, Hatsukami TS, Yuan C. Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study. Radiology. 2006 Nov;241(2):459-68. PubMed PMID: 16966482; PubMed Central PMCID:PMC1820770
  15. Kerwin WS, Oikawa M, Yuan C, Jarvik GP, Hatsukami TS. MR imaging of adventitial vasa vasorum in carotid atherosclerosis. Magn Reson Med. 2008 Mar;59(3):507-14. PubMed PMID: 18306402
  16. Demarco JK, Ota H, Underhill HR, Zhu DC, Reeves MJ, Potchen MJ, Majid A, Collar A, Talsma JA, Potru S, Oikawa M, Dong L, Zhao X, Yarnykh VL, Yuan C. MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T. AJNR Am J Neuroradiol. 2010 Sep;31(8):1395-402. PubMed PMID: 20651015
  17. Yuan C, Beach KW, Smith LH Jr, Hatsukami TS. Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging. Circulation. 1998 Dec 15;98(24):2666-71. PubMed PMID: 9851951.
  18. Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C. Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation. 2002 Sep 10;106(11):1368-73. PubMed PMID: 12221054.
  19. Kerwin W, Hooker A, Spilker M, Vicini P, Ferguson M, Hatsukami T, Yuan C. Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque. Circulation. 2003 Feb 18;107(6):851-6. PubMed PMID: 12591755
  20. Cai J, Hatsukami TS, Ferguson MS, Kerwin WS, Saam T, Chu B, Takaya N, Polissar NL, Yuan C. In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology. Circulation. 2005 Nov 29;112(22):3437-44. PubMed PMID: 16301346.
  21. Yuan C, Zhang SX, Polissar NL, Echelard D, Ortiz G, Davis JW, Ellington E, Ferguson MS, Hatsukami TS. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation. 2002 Jan 15;105(2):181-5. PubMed PMID: 11790698
  22. Takaya N, Yuan C, Chu B, Saam T, Polissar NL, Jarvik GP, Isaac C, McDonough J, Natiello C, Small R, Ferguson MS, Hatsukami TS. Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation. 2005 May 31;111(21):2768-75. PubMed PMID: 15911695
  23. Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, Tran N, Polissar NL, Isaac C, Ferguson MS, Garden GA, Cramer SC, Maravilla KR, Hashimoto B, Hatsukami TS. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results. Stroke. 2006 Mar;37(3):818-23. PubMed PMID: 16469957
  24. Saam T, Hatsukami TS, Takaya N, Chu B, Underhill H, Kerwin WS, Cai J, Ferguson MS, Yuan C. The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessment. Radiology. 2007 Jul;244(1):64-77. PubMed PMID: 17581895.