TRANSLATIONAL CARDIAC MR RESEARCH CENTER

Vasily Yarnykh, Ph.D. has 15+ year experience in various aspects of MRI physics with extensive expertise in the quantitative MRI methodology, pulse sequence development, protocol design, neurological and cardiovascular MRI applications. Dr. Yarnykh had invented several MRI technologies including quantitative MRI methods for mapping cross-relaxation parameters in tissues (CRI), efficient blood signal suppression pulse sequences for cardiovascular imaging (quadruple inversion-recovery and multi-slice double inversion-recovery), and a fast method for B1 mapping (Actual Flip-angle Imaging, AFI), which became increasingly popular over recent years. He is an author of 60 scientific articles (17 as the first author), more than 100 abstracts, and 5 patents. The main area of his research interests is the development and clinical applications of new quantitative MRI methods. The ultimate goal of Dr. Yarnykh is to bring new quantitative imaging technologies into clinical practice, where they can provide numerous benefits as both individual diagnostic tools and measures of the therapeutic effect in clinical trials.


Publications on methodology and applications of quantitative mapping of cross-relaxation parameters in tissues:

  • Yarnykh VL. Pulsed Z-spectroscopic imaging of cross-relaxation parameters in tissues for human MRI: theory and clinical applications. Magn Reson Med 2002; 47(5): 929-939. PMID: 11979572.
  • Yarnykh VL, Yuan C. Cross-relaxation imaging reveals detailed anatomy of white matter fiber tracts in the human brain. NeuroImage 2004; 23(1):409-424. PMID: 15325389.
  • Underhill HR, Yuan C, Yarnykh VL. Direct quantitative comparison between cross-relaxation imaging and diffusion tensor imaging of the human brain at 3.0 T. Neuroimage 2009;47(4):1568-1578. PMID: 19500678.
  • Underhill HR, Rostomily RC, Mikheev AM, Yuan C, Yarnykh VL. Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model. Neuroimage 2011;54(3):2052-2065. PMCID: PMC3008309.

Fast clinically targeted MPF mapping technology:

  • Yarnykh VL. Fast macromolecular proton fraction mapping from a single off-resonance magnetization transfer measurement. Magn Reson Med 2012;68(1):166-178. PMCID: PMC3311766.
  • Yarnykh VL, Bowen JD, Samsonov A, Repovic P, Mayadev A, Qian P, Gangadharan B, Keogh BP, Maravilla KR, Henson LK. Fast Whole-Brain Three-dimensional Macromolecular Proton Fraction Mapping in Multiple Sclerosis. Radiology 2015;274(1):210-220. PMCID: PMC4314118.
  • Petrie EC, Cross DJ, Yarnykh VL, Richards T, Martin NM, Pagulayan K, Hoff D, Hart K, Mayer C, Tarabochia M, Raskind M, Minoshima S, Peskind E. Neuroimaging, Behavioral, and Psychological Sequelae of Repetitive Combined Blast/Impact Mild Traumatic Brain Injury in Iraq and Afghanistan War Veterans. J Neurotrauma 2014;31(5):425-36. PMCID: PMC3934596.
  • Yarnykh VL. Time-efficient, high-resolution, whole brain three-dimensional macromolecular proton fraction mapping. Magn Reson Med 2016;75(5):2100-2106. PMCID: PMC4688249.
  • Naumova AV, Akulov AE, Khodanovich MY, Yarnykh VL. High-resolution three-dimensional macromolecular proton fraction mapping for quantitative neuroanatomical imaging of the rodent brain in ultra-high magnetic fields. Neuroimage. 2017; 147:985-993. PMID: 27646128. PMCID: PMC5303642.

Development of new B1 and T1 mapping methods:

  • Yarnykh VL. Actual flip-angle imaging in the pulsed steady state: a method for rapid three-dimensional mapping of the transmitted radiofrequency field. Magn Reson Med 2007; 57(1):192-200. PMID: 17191242.
  • Yarnykh VL. Optimal radiofrequency and gradient spoiling for improved accuracy of T1 and B1 measurements using fast steady-state techniques. Magn Reson Med 2010; 63(6):1610-1626. PMID: 20512865.
  • Hurley SA, Yarnykh VL, Johnson KM, Field AS, Alexander AL, Samsonov AA. Simultaneous variable flip angle-actual flip angle imaging method for improved accuracy and precision of three-dimensional T(1) and B(1) measurements. Magn Reson Med 2012;68(1):54-64. PMCID: PMC3295910.

Efficient blood signal suppression techniques for cardiovascular imaging:

  • Yarnykh VL, Yuan C. T1-Insensitive flow suppression using quadruple inversion-recovery. Magn Reson Med 2002; 48(5): 899-905. PMID: 12418006.
  • Yarnykh VL, Yuan C. Multislice double inversion-recovery black-blood imaging with simultaneous slice reinversion. J Magn Reson Imaging 2003; 17(4): 478-483. PMID: 12655588.
  • Yarnykh VL, Yuan C. Simultaneous Outer Volume and Blood Suppression by Quadruple Inversion- Recovery. Magn Reson Med 2006; 55(5):1083-1092. PMID: 16598725.
  • Yarnykh VL, Terashima M, Hayes CE, Shimakawa A, Takaya N, Nguyen PK, Brittain JH, McConnell MV, Yuan C. Multi-contrast Black-blood MRI of Carotid Arteries: Comparison between 1.5 and 3 Tesla Magnetic Field Strengths. J Magn Reson Imaging 2006; 23(5):691-698. PMID: 16555259.