TRANSLATIONAL CARDIAC MR RESEARCH CENTER

Late gadolinium enhanced magnetic resonance imaging (LGE MRI) enables detection, characterization and accurate quantification of acute and chronic myocardial infarction. LGE images are acquired at ~10 min after intravenous injection of MRI gadolinium-based contrast agent. Gadolinium accumulates in damaged tissues with permeable cell membranes and visible on LGE MRI as bright areas, while viable myocardium is dark. Quantification of infarct size with LGE MRI has been validated against true infarct size as verified by histochemical staining with triphenyl tertazolium chloride (TTC) in animal models. Infarct size measured on LGE MRI directly relates to LV remodeling and is a stronger predictor of future events than measures of LV systolic performance.