TRANSLATIONAL CARDIAC MR RESEARCH CENTER

Authors: Yen-Wen Liu, Mineo Iwata, Elina Minami, V. Kraig Abrams, Creighton Don, Anna V. Naumova, Amy M. Martinson, Shin Kadota, Wen-Huang Lee, Li-Tan Yang, I-Chuang Liao, Hung-Wen Tsai, Charles E. Murry, Beverly Torok-Storb.

Journal: Advances in Tissue Engineering and Regenerative Medicine, 2017, 3(1): 00055. DOI: 10.15406/atroa.2017.03.00055

Abstract: This study demonstrated a therapeutic benefit of a single intravenous infusion of DS-1 cells during the subacute MI period. Based on cell out-growth and DS-1 specific PCR assays there were no detectable DS-1 cells in the dogs after 48hours. This corroborates previous studies that also indicated DS-1 cells do not engraft, but are sequestered and cleared in the lung within 48 hours. Given that circulating monocytes express activation antigens within hours of DS-1 infusion and that we previously showed monocytes in contact with this class of fibroblasts express genes associated with multicellular organismal development, we hypothesize that the DS-1 effect is indirect and mediated by monocyte derived activities.